The Pediatric Neurovascular Anomalies Consortium (PNAC) is an international research collaboration studying rare blood vessel conditions of the brain and spine that develop before birth or during childhood. PNAC follows children over time and collects clinical information, imaging, and biological samples to better understand these conditions and support the development of future treatments and clinical trials.
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Project 1: Natural History of Pediatric Neurovascular Anomalies
Principal Investigator: Christine Fox and Heather Fullerton
The purpose of Project 1 is to characterize the natural history of rare childhood brain and spine neurovascular anomalies through a well-supported patient registry. The project will also assess how social determinants of health may influence disease outcomes and evaluate patient-reported outcomes to help identify condition-specific outcome measures for use in future clinical trials.
Project 2: Molecular Characterization of Pediatric High Flow Neurovascular Anomalies
Principal Investigator: Helen Kim and Shantel Weinsheimer
The purpose of Project 2 is to genetically characterize pediatric high-flow neurovascular anomalies and identify non-invasive circulating protein biomarkers that may help monitor or predict disease severity. The project seeks to improve understanding of these conditions and support the development of better diagnostic and monitoring tools for children with high-flow neurovascular anomalies.
Project 3: Advanced Neuroimaging of Pediatric Neurovascular Anomalies
Principal Investigators: David Saloner
The purpose of Project 3 is to determine whether imaging biomarkers of blood flow and endothelial injury are associated with venous outflow stenosis, aneurysm formation, and collateral venous recruitment, which are considered surrogates for a high risk of hemorrhage. The project will also evaluate whether imaging biomarkers of blood flow and tissue perfusion are associated with evidence of ischemic brain injury and develop a panel of imaging biomarkers to help identify and predict potential treatment risks for children with high-flow neurovascular anomalies.