Predictors of Growth, Recurrence, and High-risk Features in Pediatric Brain Arteriovenous Malformation


Principal Investigator

Research Manager 

Research Coordinators


About Project 1 

Brain arteriovenous malformations (AVMs) are abnormal tangles of blood vessels that can rupture and bleed, and are the leading cause of hemorrhagic stroke in children. Doctors can cure some AVMs and prevent stroke through a surgery or treatment with radiation. However, in some children, these AVMs will grow back after treatment. The factors that cause these vessels to grow, recur, or rupture are not well understood. Project 1, Predictors of Growth, Recurrence, and High-risk Features in Pediatric Brain Arteriovenous Malformation, will study children who have been diagnosed with brain (AVM). This study will look at imaging characteristics and blood tests to determine genetic, protein, and other biomarkers that may explain how abnormal blood vessels grow or change over time. By understanding when AVM features develop, doctors will be better able to monitor brain AVMs and develop new drug treatments which currently do not exist.